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The Powerpuff Girls is a 2022 American live-action/animated action-adventure superhero comedy film directed by Matt Reeves, with a screenplay by Chris Terrio. It is the second film adaptation of the Cartoon Network animated television series The Powerpuff Girls (1998-2005) and a standalone sequel to The Powerpuff Girls Movie (2002). The film stars Will Ferrell, Benedict Cumberbatch, Sadie Sink, Mckenna Grace, Dafne Keen, Tom Hiddleston, Jessica Chastain, Mia Bagley, Courteney Cox, Jack Black, Anna Kendrick, Ben Schwartz, and Kelsey Grammer. The events of the film take place at the end of the franchise, as the Powerpuff Girls are in their teenage years as they stop their old arch-enemies from taking over the world.

Produced by Legendary Pictures, The Powerpuff Girls Movie was released in theaters on August 20, 2022, by Warner Bros. Pictures.

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The film's score is composed by John Debney. Debney also rewrites The original show's theme song, which plays throughout action scenes in the movie. In the beginning of the film, the reboot's theme song, "Who's Got the Power?" was covered by Lady Gaga. Two songs from The Powerpuff Girls Movie were covered in the film's end credits, "That's What Girls Do" was performed by Tori Kelly and "Powerpunk Girls" was performed by Green Day.

In July 17, 2022, it was announced that Debney composed the film's score by rewriting the score of Where the Wild Things Are, Avengers: Infinity War, Avengers: Endgame, Spider-Man, Jurassic World, Zack Snyder's Justice League, Thor: Ragnarok, The Back to the Future Trilogy, Sonic the Hedgehog, and Sonic the Hedgehog 2.

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