Donny comes to the girls for protection when he's hunted by a robotic unicorn. After narrowly escaping, he reveals he accidentally released evil unicorns from a magic mirror upon Unicorn Land and needs their help to save his dimension.
The Professor has the girls visit a retirement home and interact with the elderly, Buttercup isn't too thrilled at doing so, but meets an old woman who claims she was a superhero from the 70's dubbed Green Wing.
When Bubbles's video of Blossom and Buttercup sneezing at the same time becomes a viral hit, she becomes all pretentious and makes a scripted video of basically the same thing.
Each of the girls are faced with a separate dilemma: Buttercup with a monster dog that multiplies when it gets hit, Blossom with a destructive robot at the library, and Bubbles with helping a farmer cross a river. They each tap into one another's identities in accomplishing their goals.
The girls and the Professor go on an outing to a lake where Buttercup is determined to catch the legendary crawdad One Claw McCraw. With Bubbles as her first mate, she has to compete with Princess Morbucks and her Cash Money Crew for it.
Buttercup plays a perfect round of mini-golf and wants to keep her winning ball, but is told by the creepy proprietor that she has to return it, but she keeps it anyway.
The girls' day at the beach is disrupted when the Bro Sharks take over. The girls must overcome their differences and work together when the Bro Sharks challenge them to a volleyball game.
Blossom and Buttercup destroy Schedulebot and hide it in the ground outside. However it comes back from the ground and reveals itself to them.Bubbles becomes a detective in search of the culprits. Blossom and Buttercup do their utmost to keep the truth from coming out.
Buttercup‘s intentions of getting buff go too far after she overworks at the gym and takes a toll on her crime-fighting abilities when she has to fight the Gnat.
During Career Day at school, the Professor proves to be extremely boring. The girls visit him at his job at TechCo where he introduces a suit that enables its wearer to run faster, repel bullets and activate its own weaponry.
Bubbles wants to prove she's responsible enough to own a dog, so she takes a job as a dog sitter. The dog, a pug named Paulie, keeps stopping and wanting stuff which Bubbles grudgingly gives into.
The girls attend a space camp for two weeks, but it's not what Blossom thought it would be. Instead of learning all about the space program, it's all kiddie attractions in the guise of space stuff, and it hurts and annoys Blossom.
While going through the Professor's collection of memories of the girls' exploits, Bubbles finds nothing about her and thus questions her worth as a superhero.
The girls and the Professor spend a vacation at the Abundant Aranita Resort, which is run by Javier Xavier. But the vacation is suddenly interrupted by the invasion of a mysterious creature.
When Bubbles' imagination causes a bit of a calamity at school, HIM sees it as an opportunity. He taps into Bubbles' dreamscape and turns the place into a hellish landscape, so sisters must find a way to stop it.
The Powerpuff Girls and Jared Shapiro get trapped inside the board game Phantasm Chasm. Meanwhile, Buttercup is forced to team up with Jared in order to save her sisters.
Blossom is beset with a toothache on the day the girls have their teeth cleaned at the dentist. After Buttercup tells her about cavity fixing at the dentist, she is scared out and skips the visit, lies about seeing the dentist, and gets more and more grotesque as the swelling increases.
While trying to steal a weapon called "The Apocalipstick," Mojo Jojo is confronted by the Fashionistas, who have the same goal in mind. Mojo and Bianca's sister Barbarus suddenly fall in love with each other.
The girls receive an invitation to the wedding of Mojo Jojo and Barbarus Bikini. Bianca Bikini shows up and asks for the girls' help in stopping the wedding under the presumption of evil doings.
The girls hang out with their new big sister Bliss, who gets a taste of fighting bad guys as part of the Powerpuff Girls, especially when they repeatedly find themselves dealing with the Gnat.
The Mayor is haunted by a monster roaming the halls of his office. The girls, dressed for Halloween, investigate, only to find that the Mayor himself is the monster.
After terrorizing Townsville during the holidays, Mojo Jojo is visited that night by three ghosts resembling the Powerpuff Girls who try to make him change his ways.
Being overwhelmed with work, Bubbles creates a clone of herself to make it less of a hassle, while Buttercup suspects Bubbles is an alien. However, this clone is hiding a very dark secret...
Buttercup grows out her hair in order to have a mullet but comes down with a case of Super Lice. To combat it, the Professor shrinks down Blossom and Bubbles to clear out the lice.
Jemmica returns, asking for help to retrieve an artifact known as the Cube of Doom. Blossom and Bubbles, remembering their last encounter with her, refuse. But Buttercup bored due to the downtime from any crime fighting, offers to help despite Blossom's objections.
Due to drinking tons of soda in order to teach Bubbles how to burp, the girls come down with super-powered hiccups. They try to wait for their hiccups to go away, but when the Gnat comes to attack Townsville, the girls have to try to stop him while trying to avoid causing more trouble to the town.
Mojo, tired of a string of failures, decides to try and find the girls' weaknesses by taking their prized toys and using a machine to allow them to talk. However, getting the toys to spill their deep secrets turns out to be harder than he thought.
After one of the Derbytantes injures herself during a Deathball game, Bubbles volunteers to replace her. Even though Bubbles is nervous at first, she comes to like playing on the team. However, this spotlight shining makes Buttercup jealous.
The usually happy-go-lucky Bubbles goes into a blue funk, which puzzles Blossom and Buttercup. They try to cheer her up, but none of them work, much to their annoyance. The girls' battle against the monster Harmadillo may tie into all this.
A nanny-esque woman named Deb O'Nair is aghast at the girls' behavior while they fight Mojo Jojo. The Professor, feeling he isn't raising the girls right, has Deb O'Nair visit and show them proper ladylike etiquette.
Manboy returns with a cannon that plants beards on everything. When Bubbles gets hit with the ray, she gets a beard and has taken on a behavior similar to Manboy.
Bubbles and Buttercup get into trying to contact aliens and build a gate with the help of one of their classmates, Barry. Blossom dismisses that aliens aren't real and the gate doesn't seem to work.
