Powerpuff Girls Wiki
Blisster Sister
Season 2, Episode 25
Episode name pun on: The Powerpuff Girls episode "Twisted Sister", But instead of "Twisted sister", It's The character Bliss and the words "blister" and "sister"
BlissterSister titlecard.png
Airdate: September 17, 2017
Director: Nick Jennings
Bob Boyle
Story: Julia Vickerman
Cheyenne Curtis
Writer(s): Jake Goldman
Haley Mancini
See also
"Bliss Reminisce"
"Breaking Bliss"

Blisster Sister is the twenty-fifth episode (and the sixty-fourth episode) of Season 2 of 2016 Powerpuff Girls series. It's a third part of the special movie event Power of Four.


The Girls hang out with their new big sister Bliss, who gets a taste of fighting bad guys as part of the Powerpuff Girls, especially when they repeatedly find themselves dealing with the Gnat.




Main Characters

Minor Characters

  • the Gnat
  • Students of Midway Elementary School


  • There's a recurring running gag in this episode when the Gnat keeps showing up to confront the Girls, while the Girls keep fighting over Bliss until she loses her power.
  • This episode reveals the Gnat was mutated by a radioactive microwave and was bitten by a man.
  • Bliss wears a spider costume is similar of the Marvel superhero Spider-Man (the Gnat's origins are also a parody of Spider-Man). Also she is later holding a costume that resembles of the DC superhero Wonder Woman.
  • This is the fourth time Bubbles bawling, the first three were "Little Octi Lost", "Tiara Trouble" & "People Pleaser".
  • The Girls can't remember who the Gnat is unlike their first encounter in "Musclecup".
  • This episode title is vaguely similar to "Twisted Sister", an episode from the original series about the 4th original Powerpuff Girl, Bunny, who fans of the original thought who Bliss was a bad re-hash of.
  • Buttercup forcing Bliss listened to heavy metal and in response to this, she commented "If it's too loud, you're too old!" This is a line DJ Ian from the 1994 movie Airheads said.


  • When the girls are in the fashion store, Bubbles' eyes are briefly pink. This happened in "Cheep Thrills".
ve Episodes
Season 1
Escape from Monster IslandPrincess ButtercupThe StayoverPainbowHorn, Sweet HornMan UpBye Bye, BellumLittle Octi LostStrong-ArmedPower-Up PuffTiara TroubleThe Wrinklegruff GalsArachno-RomancePuffdora's BoxBlue Ribbon BluesFrenemyOnce Upon a TownsvilleMan Up 2: Still Man-ingViral SpiralBubbles of the OperaSister SitterOdd Bubbles OutPresidential PunchoutCheep ThrillsFashion ForwardIn the Garden of Good and EddieRoad Trippin'The Big SleepThe Secret Life of Blossom PowerpuffHalt and Catch SilicoSecret Swapper of DoomRainy DayThe SquasheningElectric ButtercupProfessor ProofedPoorbucksSnow MonthSomewhere Over the SwingsetPeople Pleaser
Season 2
The Last DonnycornGreen Wing15 Minutes of FameSplitsvilleClawdadSuper Sweet 6A Star Is BlossomMini Golf MadnessSummer BummerThe Tell Tale SchedulebotMusclecupTake Your Kids to Dooms DayThe Bubbles-Sitters ClubButtercup vs. MathHome, Sweet HomesickMemory Lane of PainSpider SenseImagine ThatPhantasm ChasmTooth or ConsequencesMonkey LoveBridezillaFind Your BlissBliss ReminisceBlisster SisterBlisster SisterBlisstersweet SymphonyMidnight at the Mayor's MansionYou're a Good Man, Mojo JojoThe Trouble With BubblesSugar, Spice, and Super LiceThe Buttercup JobA Slight HiccupToy PloyDerby DolliesBubbles the BlueDeb O’NairMan Up 3: The Good, the Bad, and the ManlyThe Blossom FilesNot So Secret Service
Season 3
Never Been BlissedAliverWorshipBlossom3Mojo the GreatTrouble ClefSave the DateCan't Buy LoveLargoBlundercupRagnarock and RollTotal Eclipse of the KartThe Long Skate HomeQuarantineIn the DoghouseSalamanderSmall World: Abra-DisasterSmall World: Stone Cold SpiderSmall World: Maze DazeSmall World: Heart to HeartstoneWitch's CrewThe GiftOh, Daisy!Brain FreezeLights Out!Bucketboy!The FogThe SpoonCat BurglarHustlecupRebel RebelOur Brand is ChaosTagalongBrainLordCheckin Out!Drama BombWatch It!Man Up 4: The Donnyest GameThe Oct-FatherSideline Dad
Who's Got the Power?Air ButtercupBubbles' Beauty Blog (but on Video)Run, Blossom, Run!Ping Pong ZBubbs & Donny Get the MailBedtimeMojo Builds a ShelfI’ll Be BakeBlissfully Unaware