Nah, that honor goes to the 2016 reboot given what Nick Jennings and Bob Boyle did to that "sequel."
But we almost got a live action version of the series by the CW involving adult human Powerpuff Girls that treated the original series as something that was based off of the real-world version, which is both pretentious and gross.
PPGZ was weird and different in its own ways, but it was still excusable and more innocent since they didn't market it as a "sequel," nor did they shove that idea down everyone's throat about it.
